Seasonal coronavirus protective immunity is short-lasting

Long-Lasting Protective Immunity to

Dendritic Cell-Specific Antigen Delivery by Coronavirus Vaccine Vectors Induces Long-Lasting Protective Antiviral and Antitumor Immunity

Efficient vaccination against infectious agents and tumors depends on specific antigen targeting to dendritic cells (DCs). We report here that biosafe coronavirus-based vaccine vectors facilitate delivery of multiple antigens and immunostimulatory cytokines to professional antigen-presenting cells in vitro and in vivo. Vaccine vectors based on heavily attenuated murine coronavirus genomes were ...

immune priming against Drosophila Pseudomonas aeruginosa is short - lasting and depends on cellular and humoral immunity

Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in and Drosophila melanogaster other invertebrates during the last decade have challenged this dogma, questioning the boundaries between innate and adaptive immunity. Studies on repeated inocula...

Drosophila immune priming against Pseudomonas aeruginosa is short-lasting and depends on cellular and humoral immunity

Immune responses are traditionally divided into the innate and the adaptive arm, both of which are present in vertebrates, while only the innate arm is found in invertebrates. Immune priming experiments in Drosophila melanogaster and other invertebrates during the last decade have challenged this dogma, questioning the boundaries between innate and adaptive immunity. Studies on repeated inocula...

Humoral immunity to West Nile virus is long-lasting and protective in the house sparrow (Passer domesticus).

The house sparrow (Passer domesticus) is a common and abundant amplifying host of West Nile virus (WNV) and many survive infection and develop humoral immunity. We experimentally inoculated house sparrows with WNV and monitored duration and protection of resulting antibodies. Neutralizing antibody titers remained relatively constant for >or= 36 months (N = 42) and provided sterilizing immunity ...